Born in 1969, Youssef Tohme graduated from the French university of architecture, l'École d'Architecture Paris-Villemin, where he returned to teach theory and representation classes in 2004. During 2001-2002, he worked as a chief architect on the redesign study of the Gare d'Austerlitz at AREP.
A year later he became an assistant chief architect at Atelier Jean Nouvel Paris on project Landmark in Beirut. In 2004 he became chief architect on the preliminary phase of the Louvre Abu Dhabi Museum. At the same time, he worked in Lebanon in collaboration with 109architectes on the Campus de l'innovation, de l'économie et du sport à Beyrouth (USJ) project, which is currently under construction. In January 2008, he opened his own office in Lebanon.