Keble College of Oxford University has assigned a contract to BAM Construction to deliver a new £50m building, which is the largest contract bagged by the company in England.
Scheduled to break ground in early July this year, BAM will develop the new H B Allen Centre that would accommodate 230 rooms for graduates and research facilities surrounding a new college quad.
The project will see the demolition of the existing Acland private hospital.
The new building is slated to be completed in 2018 and will also feature a gym, cafe and a lecture hall with 120 seats.
London's Rick Mather Architects serves as the designer of the building project. The architecture firm earlier had designed the Ashmolean Museum and two other buildings for Keble College.
A new courtyard will be formed above an excavated basement.
Anthony Nagle, who has led BAM's work in Oxford since 2008, said: "This scheme re-unites us with Rick Mather architects, the designers behind our work at the Ashmolean Museum here when I first came to Oxford.
"It's a pleasing testament to our work on that scheme and on the recent Softbridge building for St Antony's College, that we're trusted to deliver what will be another challenging development for the City and education in the UK."
With the new project, BAM crosses a £200m milestone in delivering its works in Oxfordshire over the past 12 years.
Keble College Bursar Roger Boden said: "It matters to us that we are dealing with a firm that, although multinational, has deep roots in the region and a team that guards its reputation jealously.
"We chose BAM primarily because of its strong focus on collaborative teamwork."
Image: BAM will deliver a new £50m building for Keble College. Photo: courtesy of BAM.