Foster + Partners has been appointed to design the 71ha Biometropolis health city campus in the south of Mexico City.
The low-carbon, mixed-use development will create a new nature reserve to preserve the area's indigenous plants and animal species.
The sensitive development will include offices, apartments, shops and amenities around the Pedregal lava fields and features public piazzas, and pedestrian streets and courtyards.
An aquifer will minimise water shortages and rainwater will be harvested from roofs, roads and open spaces.
Solar-powered electric vehicles such as the bus connection to the nearby university station are part of the sustainable measurements.
The scheme also integrates hotel facilities for visitors to the hospital, a conference centre, facilities for bio-tech industries and clinical studies, and a number of specialist units.